Phoenix winnonlin software manual#
Phoenix winnonlin software software#

Phoenix winnonlin software manual#

Standardized Microsoft Word reports containing the full NCA analysis results can be generated seamlessly and reproducibly without the need for any manual copy-paste approach.

Phoenix winnonlin software software#

The most familiar versions of WinNonlin (v3 v5) were stand-alone Windows-based software packages used to perform non-compartmental analysis and single subject non-linear model fitting. High-quality, report-ready NCA results can be generated in a reproducible script-based manner. WinNonlin is a pharmacokinetic software package that has grown and evolved over the past 20 years. NCA can be conducted efficiently within the same environment as modeling analyses, allowing modelers an additional data diagnostic tool. An important aspect was to ensure that on one hand the calculation is correct, and at the same time to ensure numerically identical results to the Gold Standard Winnonlin. Several iterations over these steps were conducted on real NCA projects. In the third step, functions were implemented to transform NCA results into report ready tabular and graphical representations. In a second step handling of input datasets was implemented, supporting the modeler in setting up datasets in a correct way. 3 Introduction Phoenix is Pharsight s new desktop software platform that provides a cohesive environment for data analysis, modeling, and simulation. In the first step, the main underlying computational functionality for NCA was implemented, allowing to use an automatic selection of PK samples to consider for the terminal slope calculation but also allowing a modeler to select these points on an individual level. The SolutionДЄn agile approach to the development of such an NCA package was chosen. Description: Phoenix WinNonlin is the name of the engineering and specialized software of Certara Group in the field of PK / PD simulations and modeling. Additionally, functionality for efficient reporting of NCA results to Microsoft Word was sought. The goal for IntiQuan was to develop functionality in R, allowing to efficiently and reproducibly conduct script-based NCA on different types of input data, such as intravenous, bolus, and extravascular, absolute and relative (e.g., weight-based) dosing, and generating the typically required outputs in a tabular and graphical manner that are typically used in reports. Unfortunately, most of these packages lack certain functionality, user-friendliness, adequate visualization of results, or simply a good documentation and continued development. Over the last years, a multitude of open-source NCA packages have become available, allowing to script such analyses and to post-process results according to the analystвЂ™s needs. The typical use of WinNonlin is via a graphical user interface. Commercial software Phoenix WinNonlin is the most widely used NCA tool, and as such stands as the main reference tool.